Glucose Metabolism Disorders and Metabolic Syndrome Before and After Primary Hip and Knee Replacement (HyTe-2)

Coxa, Hospital for Joint Replacement

Status: Terminated

Conditions: Hyperglycemia; Hypercholesterolemia; Persistent Postoperative Pain; Knee Replacement; Hip Replacement

Study type: Observational

Funder types: Other

Identifiers

NCT01743313

HyTe-2

Details and patient eligibility

About

Osteoarthritis patients undergoing primary hip and knee replacement are followed-up and changes in their glucose metabolism and other metabolic parameters (obesity, cholesterol levels) are examined. Persistent postoperative pain is examined as secondary outcome.

Full description

Glucose metabolism disorders (diabetes and pre-diabetes) and metabolic syndrome are common in joint replacement recipients. Improved physical activity following joint replacement could lead to better glucose control in diabetes and ameliorate impaired glucose and cholesterol levels. In this study patients previously recruited to "Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement" study are being followed-up for one year in order to analyze if joint replacements have an effect on these metabolic abnormalities. In addition, the effect of glucose metabolism disorders on occurrence of persistent pain after surgery is analyzed.

Enrollment: 155 patients

Sex: All

Ages: 18 to 120 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary hip and knee replacement for osteoarthritis
• Enrolled previously into study NCT01021826

Exclusion criteria

• Arthritis other than osteoarthritis (based on study NCT01021826)
• Medication affecting glucose metabolism (excl. antidiabetic agents) (based on study NTC01021826)
• Died before follow-up phase
• Did not undergo the planned hip or knee replacement

Trial design

155 participants in 1 patient group

Hip and knee replacement recipients

Description:

Hip and knee replacement recipients (with osteoarthritis) enrolled previously into "Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement" study (NCT01021826).