Glucose Metabolism in Different PCOS Phenotypes

Medical University of Vienna

Status: Completed

Conditions: Glucose Metabolism Disorders; Polycystic Ovary Syndrome; Liver Fat; Glucose Intolerance

Treatments: Other: 1H-magnetic resonance spectroscopy; Diagnostic Test: Oral glucose tolerance test (OGTT)

Study type: Observational

Funder types: Other

Identifiers

NCT03204461

PCOS-1090

Details and patient eligibility

About

In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.

Full description

In detail an oral glucose tolerance test (OGTT) was conducted in women with the PCOS defined by the Rotterdam and the NIH-criteria, as well as in healthy control subjects. In addition 1H-magnetic resonance spectroscopy and Imaging was used for the assessment of the ectopic lipid content in the liver, heart and skeletal muscle. The aim of the present study was to compare the glucose metabolism and the ectopic lipid conent in the liver, heart and muscle between women with the PCOS defined by the NIH-criteria, Rotterdam-criteria and healthy control subjects.

Enrollment: 73 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women with the polycystic ovary Syndrome defined according to the Rotterdam and the NIH-criteria
• healthy control subjects

Exclusion criteria

• BMI>=40kg/m²
• Diagnosis of Diabetes in the PCOS-Group
• Diagnosis of Prediabetes or Diabetes in the control group

Trial design

73 participants in 3 patient groups

PCOS-NIH

Treatment:

Other: 1H-magnetic resonance spectroscopy

Diagnostic Test: Oral glucose tolerance test (OGTT)

PCOS-Rotterdam

Treatment:

Other: 1H-magnetic resonance spectroscopy

Diagnostic Test: Oral glucose tolerance test (OGTT)

Controls

Treatment:

Other: 1H-magnetic resonance spectroscopy

Diagnostic Test: Oral glucose tolerance test (OGTT)