Glucose Oxidase as Treatment Against Common Cold

Krister Tano

Status and phase: Completed; Phase 2

Conditions: Common Cold

Treatments: Drug: Saline+glucose; Drug: Glucose oxidase + glucose

Study type: Interventional

Funder types: Other

Identifiers

NCT01883440

GOcoldSY2013

Details and patient eligibility

About

Glucose oxidase is a hydrogen peroxide producing enzyme, which also is present in honey. Human rhinoviruses are sensitive to the action of hydrogen peroxide, which is documented in laboratory studies.

In the present study we aim to investigate if a nasal spray with glucose oxidase could treat a common cold, when the treatment is started even after the onset of the symptoms. The study is randomized and placebo controlled.

Full description

Persons that are convinced of that they have caught an episode of common cold can be included into the study within 24 hours after the onset of symptoms.

Before they start the treatment with the nasal spray they perform a viral sample from the nose and also fill in the WURSS-21 protocol. After this the persons spray with glucose oxidase+glucose/only saline+glucose 5 times the first day and thereafter 3 times daily for a total treatment of one week. Every day the included persons fill in the WURSS-21 protocol.

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Symptoms of a common cold within the last 24 hours

Exclusion criteria

• Use of a nasal steroid due to allergy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 2 patient groups, including a placebo group

Saline+glucose

Placebo Comparator group

Description:

A nasal spray with isotone saline + 5% glucose in a bag-on-valve nasal spray device. The spray will be administered with one puff in each nostril 5 times day one and thereafter trice daily for a total treatment time of one week

Treatment:

Drug: Saline+glucose

Glucose oxidase + glucose

Active Comparator group

Description:

A nasal spray (bag-on-valve device) with 200U/ml glucose oxidase + 5% glucose in isotone saline. One puff in each nostril 5 times daily day one and 3 times daily thereafter. A total treatment time of one week.

Treatment:

Drug: Glucose oxidase + glucose