Glutamate Modulation of tDCS Over Premotor Cortex Combined With Peripheral Nerve Stimulation Promoted Observation-execution-related Cortical Excitability and Motor Learning

Beijing Sport University

Status: Completed

Conditions: Brain Stimulation; Peripheral Nerve Stimulation; Motor Observation; Cortical Excitability

Treatments: Device: tDCS + PNS with action observation; Device: tDCS + PNS without action observation; Device: sham tDCS + PNS with action observation; Device: tDCS + sham PNS with action observation; Device: sham tDCS + sham PNS with action observation

Study type: Interventional

Funder types: Other

Identifiers

NCT06694909

GMOTOPCCWPNSPOERCEAML

Details and patient eligibility

About

This study aimed to investigate whether concurrent tDCS over the PMC and PNS during action observation enhance observation-execution-related motor cortex excitability and improve motor performance, and to explore the underlying mechanism

Enrollment: 128 patients

Sex: All

Ages: 18 to 33 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• normal or corrected-to-normal vision
• right-handed

Exclusion criteria

• pregnancy
• a history of epilepsy
• implanted medical devices
• history or presence of neurological, psychiatric or musculoskeletal disorders, other medical conditions, and left-handedness

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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128 participants in 5 patient groups

tDCS + PNS with action observation

Experimental group

Treatment:

Device: tDCS + PNS without action observation

sham tDCS + sham PNS with action observation

Experimental group

Treatment:

Device: sham tDCS + sham PNS with action observation

tDCS + PNS without action observation

Experimental group

Treatment:

Device: sham tDCS + PNS with action observation

sham tDCS + PNS with action observation

Active Comparator group

Treatment:

Device: tDCS + PNS with action observation

tDCS + sham PNS with action observation

Active Comparator group

Treatment:

Device: tDCS + sham PNS with action observation