Gluten-free Diet in Irritable Bowel Syndrome
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About
To evaluate the effects of a gluten-free diet in irritable bowel syndrome.
Full description
Irritable bowel syndrome with diarrhoea (IBS-D) is commonly encountered in primary and secondary-care practice. There are various triggers including diet. There is a growing number of people taking a gluten-free diet (GFD) of their own volition even in the absence of coeliac disease (CD). The investigators aim to assess whether a GFD could be of benefit to patients with IBS-D, previously naive to the effects of gluten and in whom CD has been excluded as per normal duodenal biopsies. The investigators will also assess whether certain factors may predict a clinical responder such as the presence or absence of at-risk coeliac serology.
Enrollment
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Ages
Volunteers
Inclusion criteria
- Patients aged 16 years or over
- Patients fulfilling ROME III symptom based criteria for IBS-D but do not have coeliac disease
Exclusion criteria
- Patients diagnosed with coeliac disease
- Patients already on a gluten-free diet
- Patients initially referred with self-reported gluten sensitivity
- Patients with organic conditions that can mimic IBS-D such as idiopathic bile acid diarrhoea, pancreatic insufficiency, microscopic colitis, and inflammatory bowel disease
Trial design
Primary purpose
Allocation
Interventional model
Masking
48 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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