Glycaemic and Insulinaemic Responses After Consumption of FOS. (GLYCOFOS-cake)

Pasteur Institute of Lille (IPL)

Status

Completed

Conditions

Glycaemia

Treatments

Other: Sugar

Other: FOS

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT02352857

2013-A00785-40

Details and patient eligibility

About

The study aims to evaluate the glycaemic and insulinaemic response of short-chain fructo-oligosaccharides (scFOS) used to replace sugars (e.g. dextrose) in foods.

Enrollment

50 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Body mass index (BMI) between 18.0 and 25.0 kg/m² (included);
Ready to keep the same volume of physical activity and the same dietary habits during the study and particularly 24 hours before each visit;
Be used to have breakfast;
Non-smoker for at least 3 months;
For the female participant: not being pregnant or breastfeeding and using efficient birth control;
Signed the consent form;
Able to follow the instructions of the study;
Health insured;
Accepted to be included in the National Registry for biomedical research Volunteers (Fichier VRB, Volontaires Recherches Biomédicales).

Exclusion criteria

Fasting blood glucose over 6.1 mmol/L (1.10 g/L) (or diabetes treated or not);
Fasting blood cholesterol over 6.35 mmol/L;
Fasting blood triglycerides over 1.70 mmol/L (or history of insulinoma);
Fasting blood insulin under 20 mU/L;
Fasting HbA1c under 7%;
History of hypercholesterolemia, hypertension, diabetes or glucose intolerance treated or not;
History of dietary allergies or coeliac disease;
History of digestive system disease susceptible to modify digestion or absorption like Crohn's disease;
Somatic or psychiatric disorders;
Renal insufficiency (kidney failure);
SGOT or ALAT over 52.5 U/L;
Smoker;
Consuming more than 3 alcoholic beverage a day;
Weight varied 3 kg the last 3 months.