Glycaemic Response and Insulinaemic Response for Nutralys S85 Plus and Whey Protein

Oxford Brookes University

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: 20 g NUTRALYS®S85 Plus pea protein; Dietary Supplement: 10 g NUTRALYS®S85 Plus pea protein; Dietary Supplement: 20 g Whey protein concentrate; Dietary Supplement: 10 g Whey protein concentrate; Dietary Supplement: 50 g Glucose

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT04871971

WT762123 (Other Identifier)

CPS-20-255

Details and patient eligibility

About

A comparison of the glycaemic response and insulinaemic response to glucose, Nutralys S85 Plus pea protein and whey protein using a single-blind, randomised, repeat measure, crossover design trial.

Full description

A single-blind, randomised, repeat measure, crossover design trial will be used to study the glycaemic response and insulinaemic response following consumption of five products: one reference product (50 g available carbohydrate Glucose) and four test products (50 g available carbohydrate Glucose with 10 g NUTRALYS®S85 Plus pea protein, 50 g available carbohydrate Glucose with 20 g NUTRALYS®S85 Plus pea protein, 50 g available carbohydrate Glucose with 10 g Whey protein concentrate and 50 g available carbohydrate Glucose with 20 g Whey protein concentrate).

Enrollment: 30 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18 to 60 years
• Body mass index (BMI) less than 30kg/m2

Exclusion criteria

• Pregnant or lactating
• Fasting blood glucose value > 6.1 mmol/l
• Any known food allergy or intolerance
• Medical condition(s) or medication(s) known to affect glucose regulation or appetite and/or which influence digestion and absorption of nutrients
• Known history of diabetes mellitus or the use of antihyperglycaemic drugs or insulin to treat diabetes and related conditions
• Major medical or surgical event requiring hospitalization within the preceding 3 months
• Use of steroids, protease inhibitors or antipsychotics (all of which have major effects on glucose metabolism and body fat distribution)
• Unable to comply with experimental procedures or did not follow GR testing safety guidelines.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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30 participants in 5 patient groups, including a placebo group

Glucose

Placebo Comparator group

Description:

Glucose 50 g available carbohydrate

Treatment:

Dietary Supplement: 50 g Glucose

10 g NUTRALYS®S85 Plus pea protein

Experimental group

Description:

50 g available carbohydrate Glucose + 10 g NUTRALYS®S85 Plus pea protein

Treatment:

Dietary Supplement: 10 g NUTRALYS®S85 Plus pea protein

20 g NUTRALYS®S85 Plus pea protein

Experimental group

Description:

50 g available carbohydrate Glucose + 20 g NUTRALYS®S85 Plus pea protein

Treatment:

Dietary Supplement: 20 g NUTRALYS®S85 Plus pea protein

10 g Whey protein concentrate

Experimental group

Description:

50 g available carbohydrate Glucose + 10 g Whey protein concentrate

Treatment:

Dietary Supplement: 10 g Whey protein concentrate

20 g Whey protein concentrate

Experimental group

Description:

50 g available carbohydrate Glucose + 20 g Whey protein concentrate

Treatment:

Dietary Supplement: 20 g Whey protein concentrate