Glycemic Index of Commonly Consumed Sweeteners

Yale University

Status: Terminated

Conditions: Healthy

Treatments: Other: Glucose50; Other: Glucose100; Other: Glucose42; Other: Oral Glucose Tolerance Test

Study type: Interventional

Funder types: Other

Identifiers

NCT02931578

1604017520

Details and patient eligibility

About

The purpose of this study is to determine the glycemic index of commonly consumed sweeteners.

Full description

This three arm study is intended to add to scientific knowledge by providing accurate assessments of the glycemic index commonly consumed food items. This will be used in the scientific literature to assess the glycemic index of foods containing various sweeteners. Participants will be monitored for a total of 10 weeks.

The glycemic index is defined as the "incremental area under the glucose response curve after standard amount of carbohydrate relative to that of a control food (white bread or glucose) is consumed." In general, the glycemic index quantifies the relative effect of the carbohydrate content of the food on resultant blood glucose.

Enrollment: 12 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 18.5-24.9 (lean)
• no medications
• no weight changes over the previous 6 months (defined as >=10% change in body weight)

Exclusion criteria

• current active participation in a weight loss program (dietary or physical activity focused)
• prior bariatric surgery
• significant medical condition such as cardiac or pulmonary disease, coagulopathy, gastrointestinal disorder, or known history of Type 1 or Type 2 diabetes
• women who are pregnant or lactating
• medications (except for oral contraceptives, thyroxins, drugs for hypertension, drugs for osteoporosis, or vitamins and minerals)
• no major medical or surgical event requiring hospitalization in the past 3 months
• no disease or drugs that influence digestion

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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12 participants in 3 patient groups

Glucose100

Active Comparator group

Description:

Participants in this arm will randomly receive 100% glucose in the OGTT drink 3 out of 9 visits.

Treatment:

Other: Oral Glucose Tolerance Test

Other: Glucose100

Glucose50

Active Comparator group

Description:

Participants in this arm will randomly receive 50% glucose in the OGTT drink 3 out of 9 visits.

Treatment:

Other: Glucose50

Other: Oral Glucose Tolerance Test

Glucose42

Active Comparator group

Description:

Participants in this arm will randomly receive 42% glucose in the OGTT drink 3 out of 9 visits.

Treatment:

Other: Glucose42

Other: Oral Glucose Tolerance Test