Glycemic Index of Table Grape Varietals

University of California (UC) Davis

Status: Completed

Conditions: Healthy

Treatments: Other: Milano grapes; Other: Table grapes; Other: Glucose beverage; Other: Grape juice

Study type: Interventional

Funder types: Other

Identifiers

NCT03248609

1086796

Details and patient eligibility

About

Investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals or grape juice, compared to a standard amount of glucose.

Full description

The study aims to investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals, compared to a standard amount of glucose. The study also aims to evaluate a new grape varietal, compared to other common table grapes, with regard to glycemic index and metabolic response related to inflammation.

Enrollment: 14 patients

Sex: All

Ages: 21 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men and women
• 21-75 years of age
• BMI range 20-35

Exclusion criteria

• adults unable to consent, individuals who are not yet adults (children), pregnant women, and prisoners.
• BMI of >35 or morbid obesity.
• Diagnosed type 1 or 2 diabetes, fasting blood glucose of >125 mg/dl, or reported use of medications or supplements known to affect glucose metabolism (insulin, sulfonylureas, metformin, glucosidase inhibitors, thiazolidinedione, insulin sensitizers, GLP-1 mimetics).
• Medications known to affect gastrointestinal motility (prokinetic agents such as reglan).
• Renal, liver, pancreatic or cardiovascular disease, uncontrolled hypertension of > 160/90, inflammatory bowel disease, disorders of esophageal and gastrointestinal motility, previous gastric resection or restriction procedures, autoimmune or immunologic disorders, anemia, breastfeeding women
• Food allergy to grapes, or inability to tolerate gluten (celiac disease).
• Poor venous access.
• Smoking, illicit drug use, consuming >7 alcoholic drinks per week.
• Weight gain or loss of > 5 kg within the prior 6 months.
• Unwillingness to adhere to study protocol.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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14 participants in 4 patient groups, including a placebo group

Milano grapes

Experimental group

Description:

Unique grape varietal to test glycemic response.

Treatment:

Other: Milano grapes

Table grapes

Active Comparator group

Description:

Common grape varietal to test glycemic response and compare to the glycemic response elicited by the Milano grape varietal.

Treatment:

Other: Table grapes

Grape juice

Active Comparator group

Description:

Used to test the glycemic response without a complex food matrix and compare to the glycemic response elicited by the Milano grape varietal.

Treatment:

Other: Grape juice

Glucose beverage

Placebo Comparator group

Description:

Used to test the glycemic response with a standardized glucose beverage and compare to the glycemic response elicited by the Milano grape varietal.

Treatment:

Other: Glucose beverage