Glycemic Response of Co-ingesting Carbohydrate and Amino Acids

Clinical Nutrition Research Centre, Singapore

Status: Completed

Conditions: Metabolic Diseases

Treatments: Other: Rice and Amino Acid mixtures

Study type: Interventional

Funder types: Other

Identifiers

NCT02455765

2014/00366

Details and patient eligibility

About

The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).

Full description

Healthy male subjects will be served with amino acid mixtures in combinations of two doses and three time points along with white rice as control. The combinations were either low or high levels of amino acid mixtures. This was consumed together or 15 min, 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of treatment meal until 60 min after the consumption of white rice. Subsequent blood sample were taken at 30 min interval until 210min. The glucose and insulin in the blood will be analysed.

Enrollment: 23 patients

Sex: Male

Ages: 21 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Chinese ethnicity
• Age between 21-50 years
• Body mass index (BMI) between 18-24.9 kg/m2
• Waist circumference ≤ 90 cm for men
• Normal blood pressure (<120/80 mmHg)
• Fasting blood glucose < 6 mmol/L

Exclusion criteria

• dislike the consumption of Essence of Chicken
• participating in competitive sports
• allergic to amino acids and rice
• metabolic diseases (such as diabetes, hypertension and the metabolic syndromes)
• Glucose-6-Phosphate-Dehydrogenase (G6PD) Deficiency
• on prescription medication
• smokers

Trial design

23 participants in 7 patient groups

White rice control

Experimental group

Description:

Subjects will consume white rice as control (50g carbohydrate)

Treatment:

Other: Rice and Amino Acid mixtures

co-ingest low dose of amino acid

Experimental group

Description:

Subjects will receive 68 ml of amino acid mixture together with white rice

Treatment:

Other: Rice and Amino Acid mixtures

co-ingest high dose of amino acid

Experimental group

Description:

Subjects will receive 136 ml of amino acid mixture together with white rice

Treatment:

Other: Rice and Amino Acid mixtures

pre-load low dose15 min

Experimental group

Description:

Subjects will receive 68 ml of amino acid mixture 15 min before consumption of white rice

Treatment:

Other: Rice and Amino Acid mixtures

pre-load low dose 30 min

Experimental group

Description:

Subjects will receive 68 ml of amino acid mixture 30 min before consumption of white rice

Treatment:

Other: Rice and Amino Acid mixtures

pre-load high dose 15 min

Experimental group

Description:

Subjects will receive 136 ml of amino acid mixture 15 min before consumption of white rice

Treatment:

Other: Rice and Amino Acid mixtures

pre-load high dose 30 min

Experimental group

Description:

Subjects will receive 136 ml of amino acid mixture 30 min before consumption of white rice

Treatment:

Other: Rice and Amino Acid mixtures