Glycemic Response to Different Food Combinations

Hospital de Santo Espírito

Status

Completed

Conditions

Postprandial Glycemia

Treatments

Other: Test meals and food baskets

Study type

Interventional

Funder types

Other

Identifiers

NCT05456672

GlucoMatchMaker

Details and patient eligibility

About

The purpose of this study is to assess the impact of combining starch rich foods with low pH foods on the glycemic response to meals

Full description

Low pH foods can attenuate the glycemic response to starch-rich foods. It has been demonstrated that lemon juice, due to its low pH (pH≈2.3) inhibited key digestive enzymes thereby interrupting gastric digestion of starch in vitro. This effect can significantly reduce the glycemic response in humans. In particular, adding lemon juice to a starch rich meal reduced the mean blood glucose concentration peak by 30%.

Considering the panoply of food options available, it is likely that other combinations have similar effects but no work has been conducted to develop a consolidated knowledge base to exploit this strategy. GlucoMatchMaker will go beyond the state-of-the art by addressing this knowledge gap. The main goal is to develop and test the real-life impact of pH-based food combination strategies on glycemic responses.

Enrollment

25 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Subject has given written informed consent
Subject is available to participate in the study sessions on the proposed dates.

Exclusion criteria

Subject has an allergy or intolerance to any food and/or ingredient in the study meals
Body mass index ≤ 18.5 kg/m2 or ≥ 30.0 kg/m2.
Diagnosed mouth, throat or active gastrointestinal pathology that may affect normal ingestion and digestion of food.
History of pancreatic disease
Subject is immunocompromised (HIV positive, transplant patient, on antirejection medications, on a steroid for >30 days, or chemotherapy or radiotherapy within the last year).
Subject has Type 1 or Type 2 diabetes mellitus or pre-diabetes.
Subject has a history of drug and/or alcohol abuse at the time of enrolment.
Subject is currently taking medication that can effect glucose metabolism and/or normal gastrointestinal function.
Subject is currently participating in another study, or plans to participate in another study during the study period.
Women of child-bearing potential who do not use an acceptable method of contraception.
Pregnant or nursing (lactating) women.