Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique

Norwegian University of Science and Technology

Status and phase

Terminated

Phase 2

Phase 1

Conditions

Headache Disorders

Trigeminal Neuralgia

Treatments

Drug: Glycerol

Study type

Interventional

Funder types

Other

Identifiers

NCT02624661

2015/1192

Details and patient eligibility

About

Trigeminal neuralgia is one of the strongest pains known to humans. Some patients do not have enough effect with the available pharmaceutical treatments and are offered a type of surgery, which involves the injection of glycerol in a nerve structure called trigeminal ganglion. The researchers will do a pilot study on 10 patients with a new surgical technique using neuronavigation. The researchers believe that this new neuronavigation-based system can improve the precision of the technique and reduce the risk for complications.

Enrollment

1 patient

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Informed and written consent
Trigeminal neuralgia defined in International Classification of Headache Disorders (ICHD)-3 criteria
Unsatisfactory effect of pharmacological treatment

Exclusion criteria

Microvascular decompression is seen as a better alternative
Heart or lung disease
Any kind of systematic or local disease or illness that may significantly increase the risk of complications for the procedure related to injection
Psychiatric illness that hinders participation in the study
Known pregnancy or breast feeding
Inadequate use of contraceptives
Overuse or abuse of opioids
Abuse of medications, narcotics or alcohol
Anomalies which hinder or impede the used method of injection
Allergy or any other hypersensitivity reactions against marcain, lidocaine, xylocain or adrenalin