Glyceryl Trinitrate Gel Phonophoresis on Planter Fasciiatis

Cairo University (CU)

Status

Not yet enrolling

Conditions

Planter Fasciitis

Treatments

Other: ultrasound only and Therapeutic exercises

Other: Phonophoresis group

Study type

Interventional

Funder types

Other

Identifiers

NCT07480876

P.T.REC/012/005852

Details and patient eligibility

About

Does phonophoresis with glyceryl trinitrate gel have an effect in treatment of planter fasciitis patients?

Full description

Plantar fasciitis (PF), considered the most common cause of sub-calcaneal pain, was first described in 1812, related to painful sensation in the calcaneus, resulting from degeneration of the plantar fascia. Some reported cases are the result of biomechanical failure that provides tension along the plantar fascia. It is a common dysfunction in runners, due to the high loads they exert on the plantar fascia, but other risk factors are also worth mentioning, such as increased planter flexion, high body mass and high body mass index phonophoresis emerges as a valuable and versatile modality within physiotherapy, demonstrating clinical efficacy across a spectrum of musculoskeletal and inflammatory conditions. The combination of topically applied gel or cream-based medications with ultrasound therapy, operating within specific frequency and intensity ranges, enhances percutaneous absorption of pharmacological agents.

Glyceryl trinitrate can directly relax vascular smooth muscles, especially the smooth muscle of small blood vessels, thus dilating blood vessels and improving the microcirculation. In addition, nitroglycerin interacts with intracellular sulfhydryl to release nitric oxide (NO). NO, as endothelial relaxing factor, activates guanylate cyclase to transform into cyclic guanosine monophosphate (cGMP), which increases cGMP in smooth muscles and other tissues, thereby causing dephosphorylation of myosin light chain, regulating the contractile state of smooth muscles, relaxing smooth muscles, and dilating blood vessels gap in literature about the effect of glyceryl trinitrate gel in treatment of plantar fasciitis. So the aim of this study is to investigate the effect of glyceryl trinitrate gel in treatment of plantar fasciitis.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 44 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age between 18-44 years .
Patients BMI 18.5 to 24.9 kg / m2.
The diagnosis of PF appear clinically according to the history and physical - examination findings of point tenderness at or near the medial calcaneal insertion of the plantar fascia .
Diagnosis of plantar fasciitis, with plantar fascia of more than 4 mm thickness as evaluated by ultrasonography.
Painful symptoms lasting three months or more .

Exclusion criteria

Diabetes mellitus, peripheral neuropathy, vasculitis and vasculopathy.
Any pathology in ankle/foot (instability, arthritis, malignancy, acute infection, and skin disorders) .
Pregnancy or lactation, coronary artery disease, hypertension, renal diseases and anemia .
Atrophy/ scar or skin ulcers at the site of intervention.
Patients with allergy to nitrates.
Heart pacemaker use .
Anticoagulant use and absence of coagulation disease.