Glycocalyx and Microcirculation in Sepsis

University Hospital Muenster

Status: Completed

Conditions: Sepsis

Treatments: Other: Microcirculation and Glycocalyx assessment

Study type: Observational

Funder types: Other

Identifiers

NCT03960307

IDF_SDF

Details and patient eligibility

About

The aim of this observative, prospective study with cross-sectional design is to explore possible correlations/associations between microcirculation parameters and sublingual endothelial glycocalyx in sepsis. Therefore, 30 critically ill septic patients and 10 healthy controls were enrolled.

Enrollment: 40 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria - septic ICU cohort:

• Sepsis (based on sepsis-3 criteria)
• ICU stay

Inclusion Criteria - healthy controls:

• Adult healthy individuals

Exclusion Criteria (for all groups):

• Underage
• pregnancy
• oral mucosal inflammation or injury

Trial design

40 participants in 2 patient groups

Septic patients

Description:

ICU patients with resuscitated sepsis, based on the sepsis-3 criteria. (n=30)

Treatment:

Other: Microcirculation and Glycocalyx assessment

Healthy controls

Description:

Apparently healthy controls (n=10)

Treatment:

Other: Microcirculation and Glycocalyx assessment