Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis

Southeast University, China

Status: Unknown

Conditions: Mechanical Ventilation Pressure High; Endothelial Dysfunction; ARDS, Human

Treatments: Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement

Study type: Observational

Funder types: Other

Identifiers

NCT03854565

Decorin-ARDS fibrosis study

Details and patient eligibility

About

ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury.

Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.

Enrollment: 336 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age > 18yrs and <80yrs
2. Meet ARDS Berlin definition
3. With mechanical ventilation

Exclusion criteria

1. have chronic pulmonary disease
2. have use heparin or low molecular heparin or chondroitin sulfuric acid

Trial design

336 participants in 3 patient groups

Mild ARDS

Description:

patients have mild ARDS according to Berlin definition

Treatment:

Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement

Moderate ARDS

Description:

patients have moderate ARDS according to Berlin definition

Treatment:

Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement

Severe ARDS

Description:

patients have severe ARDS according to Berlin definition

Treatment:

Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement