Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis

S

Southeast University, China

Status

Unknown

Conditions

Mechanical Ventilation Pressure High
Endothelial Dysfunction
ARDS, Human

Treatments

Diagnostic Test: Glycocalyx measurement,respiratory mechanics measurement

Study type

Observational

Funder types

Other

Identifiers

NCT03854565
Decorin-ARDS fibrosis study

Details and patient eligibility

About

ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury. Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.

Enrollment

336 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age > 18yrs and <80yrs
  • Meet ARDS Berlin definition
  • With mechanical ventilation

Exclusion criteria

  • have chronic pulmonary disease
  • have use heparin or low molecular heparin or chondroitin sulfuric acid

Trial design

336 participants in 3 patient groups

Mild ARDS
Description:
patients have mild ARDS according to Berlin definition
Treatment:
Diagnostic Test: Glycocalyx measurement,respiratory mechanics measurement
Moderate ARDS
Description:
patients have moderate ARDS according to Berlin definition
Treatment:
Diagnostic Test: Glycocalyx measurement,respiratory mechanics measurement
Severe ARDS
Description:
patients have severe ARDS according to Berlin definition
Treatment:
Diagnostic Test: Glycocalyx measurement,respiratory mechanics measurement

Trial contacts and locations

0

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Central trial contact

Chun C Pan, Dr

Data sourced from clinicaltrials.gov

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