Glycocalyx Damage in Critically Ill Patients

University Hospital Hradec Kralove

Status: Completed

Conditions: Critical Illness

Treatments: Device: PBR assessment

Study type: Observational

Funder types: Other

Identifiers

NCT03146585

AZVCR 9307_3

Details and patient eligibility

About

The hypothesis to be tested: GCX damage and its dynamics correlate to various patient related factors and to using organ-supporting measures. There is a correlation between length of organ support and GCX damage.

The aim of the study: Evaluation of the relationship between GCX damage and duration of various organ supporting measures.

Type of the study: Observational. Subjects: Adult patients admitted to ICU and requiring organ supporting therapy.

Sample size: We plan enrollment of 75 patients on invasive ventilatory support in the duration of least 5 days, 50 patients on renal supporting therapy lasting at least 5 days and 20 patients with target temperature management for neuroprotection.

Intervention: none Data to be recorded and analysed: Demographics, type of patients (trauma, post surgical, medical, after cardiac arrest), severity score - Apache II, SOFA, fluid balance, presence of delirium, clinical outcome, sublingual microcirculation by SDF imaging at time points: before or at the start of organ support, after 24 hours (day 1), day 3, 5, 7 and/or at discharge or before death, microcirculatory data, and Perfused Boundary Region.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients admitted to ICU
• artifitial ventilation
• renal replacement therapy
• targeted temperatura management

Exclusion criteria

• pregnant women

Trial design

40 participants in 3 patient groups

Patients on artificial ventilation

Treatment:

Device: PBR assessment

Patients on renal replacement therapy

Treatment:

Device: PBR assessment

Patients with targeted temperature management

Treatment:

Device: PBR assessment