Glycocalyx During Normothermic Machine Perfusion

Medical University Innsbruck

Status: Completed

Conditions: Liver Transplantation; Glycocalyx

Treatments: Diagnostic Test: Heparansulfate and Syndecan 1

Study type: Interventional

Funder types: Other

Identifiers

NCT04764266

Glycocalyx during NMP

Details and patient eligibility

About

An organ intended for transplantation is normally stored on ice (cold storage, CS) after explantation from the donor. During this storage process, damage to the endothelial glycocalyx occurs. It is known from numerous studies that the integrity of the endothelial glycocalyx is necessary for organ function. Normothermic machine perfusion is an alternative storage method for explanted livers, where the graft is perfused with warm blood. This study aims to clarify the influence of normothermic machine perfusion on endothelial glycocalyx damage of the graft.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• First deceased donor liver transplantation receiving a graft after normothermic machine perfusion
• Recipient age >18 years
• Written informed consent

Exclusion criteria

• Age < 18 years

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

30 participants in 1 patient group

Normothermic Machine Perfusion

Experimental group

Description:

Blood sampling at 5 time points after transplantation Perfusate collection at 3 time points during normothermic machine perfusion prior to transplantation

Treatment:

Diagnostic Test: Heparansulfate and Syndecan 1