Glycocalyx Monitoring in Major Abdominal Surgery (GLYCOCHIP)

University Hospital, Rouen

Status

Enrolling

Conditions

Major Abdominal Surgery

Treatments

Procedure: Cytoreduction surgery with Hyperthermic Intraperitoneal Chemotherapy

Procedure: Cephalic DuodenoPancreatectomy

Study type

Observational

Funder types

Other

Identifiers

NCT06285526

2023/0046/OB

2023-A00350-45 (Registry Identifier)

Details and patient eligibility

About

The study of the microcirculation and glycocalyx could be an essential element in the monitoring of our patients undergoing major abdominal surgery. It would enable us to better target the objectives of anaesthesia and resuscitation, which until now have been based essentially on macro-circulatory parameters.

Full description

This monitoring is possible in real time and real conditions by micro-camera GlycoCheck™ (Microvascular Health Solutions Inc., Salt Lake City, Utah, USA), a non-invasive monitoring allowing the study of sublingual microcirculation and glycocalyx.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

For the HIPEC group :

Adult patients
Age < 75 years
Receiving HIPEC for primary or secondary peritoneal carcinosis

For the CDP group :

Adult patient
Age < 75 years
Receiving CDP for pancreatic neoplasia
Patient who has read and understood the information letter and does not object to taking part in the study
Patient affiliated to a social security scheme

Exclusion criteria

Secondary distant peritoneal metastases
Chronic heart failure
Chronic liver failure at stage C of the Child-Pugh score
Stage IV or V chronic renal failure
Inflammation of the sublingual buccal mucosa or injury that may locally influence sublingual microcirculation
Patient refusal
Person deprived of liberty by an administrative or judicial decision or person placed under court protection or guardianship