Glymphatic MRI Study

Oregon Health & Science University (OHSU)

Status: Not yet enrolling

Conditions: Sleep Deprivation

Treatments: Other: No interventinon

Study type: Observational

Funder types: Other

Identifiers

NCT06452459

IT Gadolinium Study

Details and patient eligibility

About

This study aims at identifying neuroimaging markers of glymphatic function in humans.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ability to undergo MRI without anesthesia
• Calculated GFR greater or equal to 60 mL/min/1.73 m2

Exclusion criteria

• Inability to obtain consent
• Subject is incarcerated, pregnant, or lactating or suspects they may be pregnant
• Known allergic or hypersensitivity reactions to gadolinium
• Three or more drug allergies from separate drug classes
• Recent or expected beed for imaging with iodinated contrast
• Contraindications to MRI: claustrophobia, weight greater than maximum MRI scanner capacity, presence of metallic foreign body, or implanted devices not documented as MRI safe
• History of neurosurgical procedure or cervical surgery
• Current use of anticoagulation medications
• Contraindication to lumbar puncture (creatinine or INR elevated above laboratory standard cutoffs)