GnRH Agonist and Antagonists in an Oocyte Donation Program

Instituto Valenciano de Infertilidad, IVI VALENCIA

Status and phase

Completed

Phase 4

Conditions

Effect of Two Protocols of Ovarian Stimulation on Oocyte Quality

Treatments

Drug: Cetrorelix and Leuprolide

Study type

Interventional

Funder types

Other

Identifiers

NCT00505817

VLC-MM-0706-307-19

Details and patient eligibility

About

The primary purpose of this study is to evaluate the effect of the two different protocols (long protocol vs antagonist protocol) on oocyte / embryo quality.

Full description

The cycles with antagonists of the GnRHa present a series of advantages with respect the GnRHa in an oocyte donation program: treatment cycles are simpler and shorter, a lower amount of dose of gonadotrophins is needed for stimulation, and most important, a decreased rate of ovarian hyperstimulation syndrome is observed. Nevertheless, several clinical trials relate their use to a greater rate of abortion and worse oocyte/ embryo quality. In order to discriminate the endometrial factor from the quality of oocyte cohort, the best strategy is the oocyte donation model. In the present study, for the first time, the effect of different protocols (long versus antagonist protocol) will be studied in the same donor, acting as its own control, undergoing COH. We will compare the COH´s parameters and IVF outcome obtained in the same donor submitted to, firstly, GnRH antagonist protocol (Cetrorelix- n= 45) versus another consecutive cycle with long protocol (Ac. Leuprolide- n= 45).

Sex

Female

Ages

18 to 34 years old

Volunteers

No Healthy Volunteers

Inclusion criteria