GnRH Agonist as Luteal Support in FET Cycles

Turku University Hospital (TYKS)

Status and phase: Completed; Phase 4

Conditions: Infertility

Treatments: Drug: Natural cycle: Triptorelin acetate 0.1 mg; Drug: Hormone replacement cycle and triptorelin acetate 0.1 mg

Study type: Interventional

Funder types: Other

Identifiers

NCT02620124

T5/2013

Details and patient eligibility

About

Back ground: A single dose of GnRH analogue in the luteal phase is reported to improve the outcome of IVF/ICSI treatments but the effect in FET cycles has not been reported.

Aim: To compare the results of frozen thawed embryo transfers with and without GnRHa analogue support Primary end point: IR, PR, on going PR Secondary end point: hCH, E2 and progesterone levels 14 days after thawing

Enrollment: 100 patients

Sex: Female

Ages: 20 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 20 - 45 year old women comig to frozen thawed embryo transfer

Exclusion criteria

• The age of the woman over 42 years during the initial ICF/ICSI- treatment from which the embryos derive
• Abnormal uterus
• Known abnormality of karyotype of the woman or her partner
• Severe male factor as an exclusive reason for subfertility
• Allegy for triptorelin acetate

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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100 participants in 4 patient groups

Natural cycle, control

No Intervention group

Description:

Treatment cycles with normal luteal support with progesteron

Natural cycle, intervention

Experimental group

Description:

Treatment cycles with normal luteal support with progesteron and a single dose of 0.1 mg triptorelin when the age of the embryo was 6 days: Intervention is the additional 0.1 mg triptorelin as described in the previous sentence.

Treatment:

Drug: Natural cycle: Triptorelin acetate 0.1 mg

Hormone replacement cycle, control

No Intervention group

Description:

Standard hormone replacement cycle with estrogen and progesteron

Hormone replacement cycle, intervention

Experimental group

Description:

Standard hormone replacement cycle with estrogen and progesteron and a single dose of 0.1 mg triptorelin when the age of the embryo was 6 days

Treatment:

Drug: Hormone replacement cycle and triptorelin acetate 0.1 mg

Drug: Natural cycle: Triptorelin acetate 0.1 mg