Goal-directed CPR Using Cerebral Oximetry

NYU Langone Health

Status: Active, not recruiting

Conditions: Ischemia; Reperfusion Injury

Treatments: Other: Non-Physiological Feedback CPR; Other: Physiological Feedback CPR

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04924985

20-00354

1R01HL151732-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The proposed study is a single-center, randomized controlled pilot trial of adults who suffer in-hospital cardiac arrests. Using cerebral oxygenation and end-tidal carbon dioxide physiological targets to predict survival and neurological outcome, the impact of physiological-feedback CPR will be assessed. 150 adult patients who have a cardiac arrest event at NYU Tisch Hospital will be randomized to one of two treatment groups: (1) Physiological-Feedback CPR or (2) Non-Physiological (Audiovisual) Feedback CPR.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. In-hospital cardiac arrest patient
2. Age ≥18 years
3. Age <80 years
4. CPR lasting ≥5 minutes

Exclusion criteria

1. Patients < 18 years of age or > 80 years of age
2. Out of hospital cardiac arrest patients
3. ≥3 acute organ failures (defined as acute renal failure requiring dialysis, fulminant liver failure i.e. liver failure with INR≥1.5, respiratory failure requiring mechanical ventilation)
4. Repeat in-hospital cardiac arrest event within 14 days of a prior cardiac arrest
5. Presence of known raised intracranial pressure
6. Presence of known traumatic brain injury or subarachnoid hemorrhage <14 days old, frontal lobe brain tumors or subdural hemorrhage
7. Hyperbilirubinemia >1.0 mg/dl (based on the absorption of near-infrared light by bilirubin)
8. Resuscitation using extra-corporeal membrane oxygenation (ECMO)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 2 patient groups

Physiological Feedback CPR

Experimental group

Treatment:

Other: Physiological Feedback CPR

Non-Physiological (Audiovisual) Feedback CPR

Active Comparator group

Treatment:

Other: Non-Physiological Feedback CPR