"GOLIATH" - General Or Local Anaestesia in Intra Arterial THerapy

University of Aarhus

Status and phase: Completed; Phase 3

Conditions: Cerebral Revascularization; Stroke; Anesthesia

Treatments: Procedure: Local anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT02317237

GOLIATH

Details and patient eligibility

About

Patients suffering a stroke with a large vessel occlusion is often treated intra veneous thrombolyse and on top of that also intra arterial therapy. It is unknown what form of anaestesia is best during intra arterial therapy. The investigators will randomize these patients between general anaestesia and local anaestesia. Outcome will be growth of the ischemic lesion as judged on an MRI scan.

Enrollment: 128 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• NIHSS>10
• mRS=<2
• groin puncture<6hours from stroke onset
• occlusion of ICA, ICA-T, M1, M2

Exclusion criteria

• MRI contraindications
• GCS<9
• intubated prior to arrival
• posterior circulation stroke
• allergy to anestetics

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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128 participants in 2 patient groups

General Anesthesia

No Intervention group

Description:

The patients, who will receive general anesthesia during intervention

Local Anesthesia

Experimental group

Description:

The patients, who will receive local anesthesia/conscious sedation during intervention

Treatment:

Procedure: Local anesthesia