GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study (DHC-GON-1)

Jakob Møller Hansen, MD.

Status and phase: Unknown; Phase 4

Conditions: Chronic Migraine

Treatments: Drug: Betamethasone and local anesthetic

Study type: Interventional

Funder types: Other

Identifiers

NCT02686983

DHC-GON-1

Details and patient eligibility

About

Infiltration of the greater occipital nerve (GON) with local anaesthetics and corticosteroids is a treatment option for cluster headache. Corticosteroids may be helpful in reducing the pain intensity and frequency in chronic migrtaine. This RCT is set up to assess efficacy and safety of sub-occipital steroid injections with local anesthetic in patients with chronic migraine.

Full description

Infiltration of the greater occipital nerve (GON) with local anaesthetics and corticosteroids is a treatment option for cluster headache. In general, there is a marked paucity of evidence concerning GON blocks in migraine. Corticosteroids may be helpful in reducing the pain intensity and frequency in these patients. This is an RCT to assess efficacy and safety of sub-occipital steroid injections with local anesthetic in patients with chronic migraine.

Enrollment: 34 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic migraine

Exclusion criteria

• Medication overuse headache

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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34 participants in 2 patient groups, including a placebo group

Active

Experimental group

Description:

Betamethasone and local anesthetic.

Treatment:

Drug: Betamethasone and local anesthetic

Placebo

Placebo Comparator group

Description:

Saline with local anesthetic.

Treatment:

Drug: Betamethasone and local anesthetic