GPIAG and Leicester Asthma and Dysfunctional Breathing (GLAD) Study: a Randomised Controlled Study

P Burns

Status and phase: Completed; Phase 3

Conditions: Asthma; Respiratory

Treatments: Other: Physiotherapist

Study type: Interventional

Funder types: Other

Identifiers

NCT00515840

03/014

Details and patient eligibility

About

Breathing retraining supervised by a physiotherapist will result in improvements in the quality of life and asthma control of patients treated for asthma in the community with symptoms suggestive of dysfunctional breathing.

To investigate the effects of breathing retraining on clinical and physiological parameters of asthma control, to identify the characteristics of patients who benefit, to perform a health economic evaluation.

Full description

Objectives:

• To assess the effect of breathing retraining on asthma-related health status, asthma control and objective indices of asthma severity (bronchial hyper-reactivity (BHR), sputum eosinophilia and nitric oxide production) in patients with symptomatic asthma.
• To compare the relationship between symptoms of dysfunctional breathing (Nijmegen Questionnaire screening score), changes in asthma-related health status and other parameters resulting from breathing retraining
• To explore the relationship between dysfunctional breathing, baseline asthma symptoms, treatment and asthma-related quality of life.
• To estimate the cost effectiveness of the breathing retraining intervention

Enrollment: 182 patients

Sex: All

Ages: 17 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Asthma diagnosis in medical records
• Age 17-70 yrs.
• One or more prescription for asthma medication in previous 12 months
• Impaired asthma related quality of life (AQLQ score <5.5)

Exclusion criteria

• COPD
• Unstable or under-treated asthma at enrollment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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182 participants in 1 patient group

1

Sham Comparator group

Description:

equal time with health care professional (asthma nurse)

Treatment:

Other: Physiotherapist