GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR

University of Florida

Status

Withdrawn

Conditions

Transcatheter Aortic Valve Replacement

Glutathione Peroxidase Activity

Aortic Stenosis

Treatments

Diagnostic Test: Blood draw to measure SOD activity

Diagnostic Test: Blood draw to measure Lp(a) levels

Diagnostic Test: Blood draw to measure GPx activity

Study type

Observational

Funder types

Other

Identifiers

NCT04268160

IRB201902486

Details and patient eligibility

About

The aim of this project is to investigate the association of glutathione peroxidase (GPx) and severe aortic stenosis (AS), as well as the impact of transcatheter aortic valve replacement (TAVR) on GPx activity post-procedure. The burden of oxidative stress will be determined by the measurement of GPx, superoxide dismutase (SOD) and lipoprotein A (Lp(a)). We hypothesize GPx activity is reduced in participants with severe AS vs control groups and GPx activity is to increase after TAVR is performed.

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age >18 years
Patients with severe AS including participants with low flow, low gradient severe AS and paradoxical severe AS
Patients meeting criteria for TAVR procedure

Exclusion criteria