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GR Defect in Peripheral Blood Mononuclear Cells in COPD

Imperial College London logo

Imperial College London

Status

Withdrawn

Conditions

Chronic Obstructive Pulmonary Disease

Treatments

Procedure: blood test

Study type

Observational

Funder types

Other
Industry

Identifiers

NCT00159237
D5899N00007

Details and patient eligibility

About

T.to investigate a possible mechanism of the glucocorticosteroid receptors (GR) defect in patients with severe COPD by studying the effect of dexamethasone (Dex) on GR- binding, interleukin production (IL-6/IL-8) and MKP-1 expression in peripheral blood mononuclear cells blood (PBMC)

Sex

All

Ages

35 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with severe (stage III, Gold) to very severe (stage IV, GOLD) COPD or subjects who are healthy smokers or subjects who are non-smokers
  • Written informed consent

Exclusion criteria

  • Current upper respiratory tract infections
  • Any significant disease or disorder (e.g. cardiovascular, pulmonary (other than asthma), gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment) which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or may influence the results of the study, or the subjects ability to participate in the study
  • Subjects not considered capable, as judged by the investigator, of following instructions of the study, e.g. because of a history of alcohol or drug abuse or any other reason

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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