Graded Exercise Hypoxia Testing

Mayo Clinic

Status: Enrolling

Conditions: Hypoxia

Treatments: Diagnostic Test: Graded Hypoxia Exercise Test; Diagnostic Test: Graded Exercise Test

Study type: Observational

Funder types: Other

Identifiers

NCT06901284

25-000497

Details and patient eligibility

About

The purpose of this study is to develop a single, standardized test to determine how individuals tolerate acute hypoxia in a stepwise fashion. We aim to evaluate the association between multiple factors, such as ventilatory compensation, heart rate response, acid-base changes, sex, pulmonary function, etc, which may explain why some individuals tolerate exercise in hypoxia better than others. Identifying these factors of association will inform future pharmacological and non-pharmacological attempts to combat acute hypoxic exercise.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Physically active (≥150 minutes of moderate physical activity per week)

Exclusion criteria

• Contraindications to exercise testing
• Currently pregnant
• Musculoskeletal or metabolic disease
• Allergies to lidocaine
• Body-mass index ≤18 or ≥35 kg·m-2
• Pacemaker
• No confounding cardiorespiratory disease
• Persistent tobacco use (>15 pack years)

Trial design

50 participants in 1 patient group

Study group

Description:

50 participants (25 female, 25 male) who are physically active for at least 150 minutes per week, at a moderate activity level.

Treatment:

Diagnostic Test: Graded Exercise Test

Diagnostic Test: Graded Hypoxia Exercise Test