Graft-versus-host Disease Associated Myelosuppression

Technische Universität Dresden

Status: Unknown

Conditions: Allogenic Disease; Abnormal Hematopoiesis; Graft vs Host Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02829216

Bone marrow GvHD

Details and patient eligibility

About

The objective is to measure the frequency, functionality and phenotype of bone marrow-derived mesenchymal stromal cells in patients after allogeneic hematopoietic stem cell transplantation. Furthermore, the immune cell infiltrate of the bone marrow will be monitored at the same time. These results will be correlated with the extent of cytopenia and clinical graft-versus-host disease grading.

Enrollment: 50 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• age >18
• acute myeloid leukemia
• myelodysplastic syndrome
• hematopoietic stem cell transplantation

Exclusion criteria

• not willing to take part