Gram Stain of the First Urine After Puncture in Percutaneous Nephrolithotomy

Adiyaman University

Status: Enrolling

Conditions: Percutaneous Nephrolithotomy

Treatments: Diagnostic Test: Gram staining of the first urine after intraoperative renal puncture to predict the systemic inflammatory response after percutaneous nephrolithotomy.

Study type: Interventional

Funder types: Other

Identifiers

NCT06393062

2022/7-17

Details and patient eligibility

About

In this study, investigators compared the systemic inflammatory responses after percutaneous nephrolithotomy (PCNL) patients who were given an expanded empirical antibiotic regimen based on the prediction of the possibility of bacteria identified by Gram staining the first urine after renal puncture and patients whose antibiotic regimen was not performed and whose antibiotic regimen was adjusted according to patient symptoms and culture results. Investigators aimed to test its diagnostic value in predicting and preventing complications.

Enrollment: 245 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with an indication for percutaneous nephrolithotomy due to kidney stone disease.

Exclusion criteria

• under 18 years old,
• having an active urinary tract infection before surgery and positive urine cultures,
• Patients with bilateral kidney stones,
• DJ stent or nephrostomy placement,
• Solitary kidney stones,
• Bleeding disorders,
• impaired kidney function,
• a history of antibiotic use for any reason within 2 weeks before randomization were excluded from the study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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245 participants in 2 patient groups

Gram staining

Experimental group

Description:

Gram staining of post-puncture urine in percutaneous nephrolithotomy

Treatment:

Diagnostic Test: Gram staining of the first urine after intraoperative renal puncture to predict the systemic inflammatory response after percutaneous nephrolithotomy.

control

No Intervention group

Description:

non-intervention percutaneous nephrolithotomy