Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia

Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne

Status: Completed

Conditions: Fungal Infection; Fever; Fever of Unknown Origin; Neutropenia; Hematological Neoplasms; Bacterial Infection; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT02544230

GTX.01

Details and patient eligibility

About

The investigators retrospectively evaluated the efficacy of granulocyte transfusions as adjunctive treatment for severe infections in neutropenic fever unresponsive to antimicrobial therapy in hematological patients.

Enrollment: 101 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• fever;
• presence of absolute neutrophil count <0.5 x 10^9/L
• evidence of bacterial or fungal infections (including clinical signs of infection, positive cultures or biopsy, and radiological evidences)
• unresponsiveness to appropriate antimicrobial therapy for at least 48 hours

Exclusion criteria

• none