Grape and Pomegranate Polyphenols in Postprandial Glucose and Related Parameters (POME-GRAPE-1)

Higher Council for Scientific Research (CSIC)

Status

Completed

Conditions

Subjects With Abdominal Obesity

Treatments

Dietary Supplement: Mixture of grape pomace and pomegranate pomace

Study type

Interventional

Funder types

Other

Identifiers

NCT02710461

AGL2014-55102-JIN_1

Details and patient eligibility

About

The aim of this is study is to evaluate the acute effect of grape and pomegranate polyphenols in the modulation of markers of metabolic syndrome. Most of the previous works about polyphenols have only considered a fraction of polyphenols, i.e., extractable polyphenols. As a consequence, an important amount of dietary polyphenols, the so-called non-extractable polyphenols are ignored. In contrast, the effect of both extractable and non-extractable polyphenols will be considered in this study. Furthermore, the effect of both polyphenols as present in the food matrix and metabolites derived from microbial fermentation will be evaluated.

Enrollment

20 patients

Sex

All

Ages

40 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Abdominal perimeter ≥102 cm. for male participants and ≥88 cm for female participants.
Subjects presenting some or several of these characteristics will be prioritized:

Fasting glucose values between 110-128 mg/dL. Triglycerides = 150-195 mg/dL. HDL-cholesterol: < 50 mg/dL men, < 40 mg/dL women. Blood pressure: systolic > 130 mm Hg; diastolic > 85 mm Hg.

Exclusion criteria

Subjects taking drugs for hyperglycaemia, hypertension or hypercholesterolaemia.
Volunteers participating in other studies or weight loss plans.
Pregnant or breastfeeding women.