Grass Sensitisation and Allergic Rhinitis in Thai Patients

Mahidol University

Status: Completed

Conditions: Allergic Rhinitis Due to Weed Pollens; Allergy to Grass Pollen

Treatments: Other: Immunoblot

Study type: Observational

Funder types: Other

Identifiers

NCT01686022

NRCT_G04

Details and patient eligibility

About

Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.

Full description

To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study.

The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.

Enrollment: 40 patients

Sex: All

Ages: 10 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Allergic rhinitis patients age 10-50 years old
• Control: healthy volunteer age 18-50 years old

Exclusion criteria

• Chronic illness such as cardiovascular diseases, liver diseases
• History of anaphylaxis
• Pregnancy

Trial design

40 participants in 1 patient group

Pollen Allergy

Description:

Pollen allergy and control will have the same intervention, ie. Skin prick test and collect serum samples.Then measure the specificIgE, immunoblot, and ELISA inhibition

Treatment:

Other: Immunoblot