Green Coffee Effect on Metabolic Syndrome

Tanta University

Status: Completed

Conditions: Supportive Care; Hypertension; Obesity; Metabolic Syndrome

Treatments: Dietary Supplement: Green coffee been extract; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05688917

FPTU-11-2020

Details and patient eligibility

About

The present study aimed to investigate the effect of green coffee bean extract (GCBE) on the inflammatory biomarkers in obese patients with a metabolic syndrome via analyzing some inflammatory biomarkers as resistin, TNF-α, total sialic acid, homocysteine, high sensitivity C-reactive protein (hs-CRP) and anti-inflammatory cytokine, adiponectin

Full description

160 obese patients supplemented with either GCBE capsules (800 mg) daily or placebo for 6 months and advised to take a balanced diet. Blood samples were collected at baseline and after three months of supplementation

Enrollment: 160 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Participants were enrolled if they were

• aged 20-60y
• waist circumference >102 cm in male; 88 cm in female
• triglycerides ≥150 mg/dL (1.7 mmol/L)
• HDL-C<40 mg/dL (1.03 mmol/L) in males & <50 mg/dL (1.29 mmol/L) in females
• systolic BP ≥ 130 or diastolic BP ≥ 85 mm Hg.

Exclusion criteria

• liver, kidney, coronary artery disease, type I diabetes, autoimmune diseases, cancer, infection, smoking, recent major surgery, routine coffee consumption, pregnancy or breast-feeding, use of anti-inflammatory drugs, corticosteroids, hormone replacement therapy, weight-loss and anti-hypercholesterolemic medications three months or less prior to enrolment

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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160 participants in 2 patient groups, including a placebo group

green been extract treated group

Experimental group

Description:

Participants included in the study were maintained on a balanced diet and supplemented with Green Coffee Bean (Coffea Arabica) extract capsules (800 mg/capsule

Treatment:

Dietary Supplement: Green coffee been extract

Placebo group

Placebo Comparator group

Description:

Participants included in the study were maintained on a balanced diet and supplemented with placebo capsules.

Treatment:

Other: Placebo