Green Coffee Extract Supplementation and Oxidative Stress, Systemic and Vascular Inflammation

National Nutrition and Food Technology Institute

Status: Completed

Conditions: Metabolic Syndrome

Treatments: Dietary Supplement: green coffee extract

Study type: Interventional

Funder types: Other

Identifiers

NCT03265184

NationalNFTI1355

Details and patient eligibility

About

Metabolic syndrome (Mets) is defined as the collection of risk factors contributing to type 2 diabetes mellitus and cardiovascular disease. Mets is accompanied by oxidative stress and low-grade inflammation. Green coffee is rich in polyphenols called chlorogenic acids (CGA) which possess anti-inflammatory and anti-oxidative characteristics. Thus, we carried out this trial to examine green coffee extract (GCE) effects on oxidative stress, systemic and vascular inflammation in patients having Mets

Enrollment: 48 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• body mass index of over 25, waist circumference >102 cm in men or >88 cm in women,Fasting blood glucose >100 mg/dL, Triglycerides (TG) > 150 mg/dL, High density lipoprotein cholesterol (HDL-C) <50 in women or <40 in men, Systolic blood pressure (SBP) >130 mmHg and diastolic blood pressure (DBP) >85mmHg

Exclusion criteria

• insulin administration for diabetes control, having hypo- or hyperthyroidism, renal failure or other chronic diseases, regular coffee consumption, pregnancy, breastfeeding, taking estrogen, progesterone, corticosteroids, weight loss supplements and obeying unusual weight loss plans

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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48 participants in 2 patient groups, including a placebo group

intervention group

Experimental group

Description:

400 mg green coffee extract capsules twice per day for 8 weeks The Green coffee extract is standardised with 45% total chlorogenic acid by HPLC

Treatment:

Dietary Supplement: green coffee extract

placebo group

Placebo Comparator group

Description:

placebo capsules twice per day for 8 weeks have identical appearance to Green coffee extract capsules and contain starch

Treatment:

Dietary Supplement: green coffee extract