Green Tea Anticancer Mechanisms in Smokers

Philip Diaz

Status

Completed

Conditions

Cancer

Treatments

Dietary Supplement: Green Tea

Other: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT01162642

2007C0109

Details and patient eligibility

About

The purpose of this study is to determine whether green tea may lower the risk of certain cancers.

Full description

Green tea contains phytochemicals, especially flavonoids. Phytochemicals are not absolutely required for normal functions, but may confer health benefits such as antioxidant actions. One can live without phytochemicals, but one may live longer and better with them. The phytochemicals in tea have been proposed to inhibit cancer onset via several different mechanisms. An obvious question is: Can anti-cancer actions of green tea be duplicated by black tea, which in the USA, is consumed more than green tea? The question remains unanswered, and will not be addressed by this project since many questions about green tea have not been answered yet. The contents of both type teas overlap in flavonoids, but green tea has more of the agents thought to be most effective. For example, some of the research cited below uses the flavonoid epigallocatechin gallate. Green tea has 5 times more of this flavonoid than black tea.

This study has two purposes. First, a case will be made that green tea may have several anti-cancer mechanisms, but this contention is not well confirmed by human intervention studies. This case will be made by addressing four questions. Second, justification will be given for the choice of mechanisms to be examined in this project's human intervention.

Enrollment

43 patients

Sex

All

Ages

23 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy 23-40 year old males and non-pregnant females, who are moderately heavy smokers (1-1.75 packs/day, > 2 years)

Exclusion criteria

Habitual tea intake
Habitual flavonoid supplementation
Soy product intake over twice a week (soy is high in flavonoids).
Pulmonary diseases
Chronic or acute infection
Admission of heavy alcohol intake (> 14 beers or drinks a week)
Body mass index (BMI) > 30 (moderately overweight subjects will be taken)
Abnormal EKG
History of heart or other major health problems (ie arthritis, diabetes).
Subjects with slightly high blood pressure will be eligible for the project, but more severe hypertension (>150/100)