Green Tea Effect on Anthropometric, Oxidation and Inflammation Parameters in Physically Active vs. Sedentary Elders (GT)

Rambam Health Care Campus

Status: Completed

Conditions: Aging

Treatments: Other: 4 daily placebo tea bags for 12 weeks; Dietary Supplement: Four green tea bags per day for 12 weeks

Study type: Interventional

Funder types: Other

Identifiers

NCT02077660

01

Rambam MC (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to evaluate the beneficial effects of a long term (12 weeks) green tea drinking on plasma, erythrocytes and saliva oxidative stress biomarkers and antioxidant capacity, as well as on cardiometabolic risk factors: anthropometric, inflammation and metabolic parameters in a healthy aging men and women.

Full description

A prospective, crossover trial in which every individual served its own control. All subjects undergo a four weeks washout period, during which they briefed to avoid tea drinking and antioxidant supplements until the end of the study. At the end of the washout period, blood and saliva samples is collected after 12 hours of night fast. Subsequently, all subjects receive the maltodextrin containing placebo "tea bags". The subjects instructed to brew the placebo sachets for five minute in 240 mL boiling water without stirring and to drink 4 cups per day for 12 weeks period (placebo period). After the placebo period, fasting samples collected once more and the subjects receive the green tea bags. Preparation and drinking instructions are the same as the placebo drink. At the end of the 12 weeks, green tea drinking, fasting blood and saliva samples drawn for the third time. During the study, every 4 weeks the subjects get additional placebo or green tea bags. Assessment of nutritional consumption of macronutrients and antioxidants using a food diary, physical activity lifestyle as well as weight, body fat and circumference measurements is made at the beginning, middle and end of the study.

Enrollment: 43 patients

Sex: All

Ages: 60 to 76 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men and women
• Age: 60-76 Years
• Able to understand the meaning of Informed Consent procedure and willing to consent

Exclusion criteria

• Any active disease state
• Unstable chronic disease (diabetes, vascular, renal)

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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43 participants in 2 patient groups, including a placebo group

4 daily placebo tea bags for 12 weeks

Placebo Comparator group

Description:

All subjects will undergo a 12 weeks supplemented with four daily placebo maltodextrin "tea-bags". The subjects will be instructed than to brew the placebo sachets for five minute in 240 mL boiling water without stirring and to drink 4 cups per day for 12 weeks period (Placebo period).

Treatment:

Other: 4 daily placebo tea bags for 12 weeks

Four green tea bags per day for 12 weeks

Experimental group

Description:

After the placebo period, all subjects will undergo a 12 weeks supplemented with four daily green tea bags. The subjects will be instructed than to brew the green tea sachets for five minute in 240 mL boiling water without stirring and to drink 4 cups per day for 12 weeks period (Green tea period).

Treatment:

Dietary Supplement: Four green tea bags per day for 12 weeks