Group A Streptococcus Saliva Study

The Hospital for Sick Children

Status: Active, not recruiting

Conditions: Group A Streptococcal Infections

Treatments: Diagnostic Test: Saliva collection

Study type: Interventional

Funder types: Other

Identifiers

NCT06473506

1000081444

Details and patient eligibility

About

This study is being done to evaluate whether saliva can be used to diagnose GAS infection and also to compare different testing methods in the microbiology lab. The saliva sample testing will be compared to the throat swab testing to see if saliva testing works as well. The lab will also try different testing methods to see if a faster type of testing (e.g. molecular testing) works as well as the regular method, which takes 48 hours to get results.

This is important because throat swabs can be challenging to collect in some children, and saliva is often much easier and more acceptable by children to collect. This could improve our ability to accurately diagnose and treat GAS infections.

Enrollment: 200 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• < 19 years of age
• Have provided a sample for GAS testing (bacterial throat swab or POCT rapid antigen test) at the discretion of the clinical team
• Able to provide a saliva sample

Exclusion criteria

• Parent/guardian and/or patient unable to consent or assent
• Unable to provide a saliva sample

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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200 participants in 1 patient group

Saliva collection

Other group

Description:

Self-collected saliva sample

Treatment:

Diagnostic Test: Saliva collection