Growth Factors in the Treatment of the Multiple Gingival Recessions

Bulent Ecevit University

Status: Completed

Conditions: Gingival Recession; Growth Factors, Combined Defect of

Treatments: Procedure: CAF+A-PRF; Procedure: CAF+CGF; Procedure: CAF only

Study type: Interventional

Funder types: Other

Identifiers

NCT05319938

HD-1726

Details and patient eligibility

About

The purpose of this study was to compare and evaluate the clinical effects of Concentrated Growth Factor (CGF) and Advanced Platelet-Rich Fibrin (A-PRF) applied together with Coronally Advanced Flap (CAF) technique using a microsurgical approach in the treatment of Type I multiple gingival recessions (GR).

Enrollment: 20 patients

Sex: All

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Systematically and periodontally healthy non-smokers
• Presence of Cairo Recession type I gingival recession with ≥ 2 mm gingival recession depth, probing depth <3 mm and gingival thickness (GT) ≥ 0.8 mm on both sides of the maxillary arch
• Width of keratinized gingiva ≥ 2mm
• Presence of identifiable cemento-enamel junction
• Full-mouth plaque index (PI) < 20 %
• Gingival index (GI) scores =1
• Presence of tooth vitality
• Absence of caries, restorations and furcation involvement in the treated area

Exclusion criteria

• Patients who had systemic problems that wound contraindicate for periodontal surgery
• Usage of medications known to interfere with healing and to cause gingival enlargement
• Recession defects associated with demineralization, deep abrasion, previous surgery in the defects area within the past 1 year
• Pregnant or lactating females
• Drug and alcohol abuse

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 3 patient groups

CAF only

Active Comparator group

Description:

Only Coronally Advanced Flap technique

Treatment:

Procedure: CAF only

CAF+CGF

Experimental group

Description:

Concentrated Growth Factor (CGF) applied together with Coronally Advanced Flap (CAF) technique

Treatment:

Procedure: CAF+CGF

CAF+A-PRF

Experimental group

Description:

Advanced Platelet-Rich Fibrin (A-PRF) applied together with Coronally Advanced Flap (CAF) technique

Treatment:

Procedure: CAF+A-PRF