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Growth Hormone Co-treatment Within a GnRH Antagonist Protocol in Patients With Poor Ovarian Response

R

Riyadh Fertility and Reproductive Health center

Status and phase

Unknown
Phase 2

Conditions

Infertility, Female

Treatments

Drug: HPuFSH/GnRH antagonist
Drug: Growth hormone/HPuFSH/GnRH antagonist

Study type

Interventional

Funder types

Other

Identifiers

NCT03373149
Gh/poor responders

Details and patient eligibility

About

In this study, the investigators will assess the efficacy of growth hormone co-stimulation to GnRH antagonist regimen in poor responders to COH for IVF.

Full description

To date, a limited number of studies have been performed in order to assess whether the addition of GH can improve the probability of pregnancy in poor responders undergoing ovarian stimulation for IVF. Moreover, the existing studies are underpowered and, thus, inconclusive.

In this study, the investigators will assess the efficacy of growth hormone co-stimulation to GnRH antagonist regimen in poor responders to COH for IVF.

Enrollment

228 estimated patients

Sex

Female

Ages

35 to 42 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Serum anti-Müllerian hormone (AMH) less than 1.2 ng/ml

Exclusion criteria

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

228 participants in 2 patient groups

Growth hormone/HPuFSH/GnRH antagonist
Experimental group
Description:
The patients receive growth hormone
Treatment:
Drug: Growth hormone/HPuFSH/GnRH antagonist
HPuFSH/GnRH antagonist
Active Comparator group
Description:
Growth hormone is not used
Treatment:
Drug: HPuFSH/GnRH antagonist

Trial contacts and locations

1

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Central trial contact

Usama M Fouda, Prof.

Data sourced from clinicaltrials.gov

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