Growth Hormone Co-treatment Within a GnRH Antagonist Protocol in Patients With Poor Ovarian Response

Riyadh Fertility and Reproductive Health center

Status and phase: Unknown; Phase 2

Conditions: Infertility, Female

Treatments: Drug: HPuFSH/GnRH antagonist; Drug: Growth hormone/HPuFSH/GnRH antagonist

Study type: Interventional

Funder types: Other

Identifiers

NCT03373149

Gh/poor responders

Details and patient eligibility

About

In this study, the investigators will assess the efficacy of growth hormone co-stimulation to GnRH antagonist regimen in poor responders to COH for IVF.

Full description

To date, a limited number of studies have been performed in order to assess whether the addition of GH can improve the probability of pregnancy in poor responders undergoing ovarian stimulation for IVF. Moreover, the existing studies are underpowered and, thus, inconclusive.

In this study, the investigators will assess the efficacy of growth hormone co-stimulation to GnRH antagonist regimen in poor responders to COH for IVF.

Enrollment: 228 estimated patients

Sex: Female

Ages: 35 to 42 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Serum anti-Müllerian hormone (AMH) less than 1.2 ng/ml

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

228 participants in 2 patient groups

Growth hormone/HPuFSH/GnRH antagonist

Experimental group

Description:

The patients receive growth hormone

Treatment:

Drug: Growth hormone/HPuFSH/GnRH antagonist

HPuFSH/GnRH antagonist

Active Comparator group

Description:

Growth hormone is not used

Treatment:

Drug: HPuFSH/GnRH antagonist