Growth Hormone Deficiency and Empty Sella Cardio-Metabolic Risk Factors in Obesity: a Cross-Sectional Study

University of Roma La Sapienza

Status: Completed

Conditions: Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT02092779

GHD2014

Dept.Exp.Med.Sapienza.Rome (Other Identifier)

Details and patient eligibility

About

Obesity is a disease not always attributable to nutritional imbalance, frequently associated with changes in key hypothalamic-pituitary (HP) axes. The regain of weight loss after hypochaloric diets has been ascribed to these HP disregulations. The aim of the study is to explore pituitary morphology and its association with pituitary function and metabolic phenotype in outpatient obese individuals evaluated in the period 2010-2013 at the Department of Experimental Medicine of the University of Rome La Sapienza, with features of HP disease in a cross-sectional .

Enrollment: 447 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult obese

Exclusion criteria

• psychiatric disturbances, pregnancy, lactation, or drugs known to affect pituitary function

Trial design

447 participants in 1 patient group

Obese patients, no treatment