Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content

University of Aarhus

Status: Completed

Conditions: Fatty Liver; Metabolism

Treatments: Drug: Somatropin and pegvisomant

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00476879

090600-deleted

Details and patient eligibility

About

The purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.

Full description

During fasting the human body is known to metabolize relatively large amounts of fat, in the expense of proteins and glucose. Partly this shift in metabolism is caused by increasing GH secretion, but exactly how growth hormone exerts these effects remains to be further investigated.

10 healthy lean young men are studied at 4 different occasions in a randomized single-blinded cross-over study. 1: after 12 hours of fasting + GH bolus, 2: after 36 hours of fasting + GH bolus, 3: after 36 hours + saline, 4: after 36 hours of fasting + Somavert.

Aim:

• to study the signal transduction in muscle and fat tissue
• to study the metabolism during fasting
• to study the intrahepatic fat content using magnetic resonance techniques

Enrollment: 10 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male
• healthy
• age 20 - 40 years of age
• BMI 20 -25

Exclusion criteria

• uses any medication
• drinks more than 21 units of alcohol per
• is claustrophobic
• carries any magnetic devices

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 4 patient groups

1

Experimental group

Description:

12 hours of fasting and a GH bolus

Treatment:

Drug: Somatropin and pegvisomant

2

Experimental group

Description:

36 hours of fasting and a GH bolus

Treatment:

Drug: Somatropin and pegvisomant

3

Experimental group

Description:

36 hours of fasting and Pegvisomant

Treatment:

Drug: Somatropin and pegvisomant

4

Experimental group

Description:

36 hours of fasting and NaCl injection

Treatment:

Drug: Somatropin and pegvisomant