Growth Parameters & Body Mass Index in Children With Chronic Diseases

Sohag University

Status: Not yet enrolling

Conditions: Chronic Medical Diseases

Treatments: Diagnostic Test: Growth parameters & body mass index

Study type: Observational

Funder types: Other

Identifiers

NCT05801718

Soh-Med-23-03-09MS

Details and patient eligibility

About

Deviations from the normal pattern of growth may be the first clues to pathology as in many chronic diseases evaluated clinically by anthropometric measurements & body mass index. Growth impairment in children with chronic diseases is associated with disruption of the growth hormone (GH) and predominantly results from undernutrition, chronic inflammation and prolonged corticosteroid treatment.

Undernutrition leads to major adaptations in the endocrine system towards conserving energy, diverting substrates away from growth and reproduction, and providing alternative sources of energy for critical body homeostasis. chronic inflammatory processes exacerbate undernutrition through proinflammatory cytokines such as interleukin-1&6 and tumor necrosis factor. These growth-regulating mechanisms are disturbed further by corticosteroids used in some chronic conditions for their anti-inflammatory and immunosuppressive properties.

Growth impairment occurs with many chronic conditions e g: Congenital heart dieases (CHD), chronic pulmonary diseases such as bronchial asthma, Gastrointestinal diseases sch as inflammatory bowel disease ,Chronic liver diseases , Chronic renal diseases, Chronic hemolytic anemia and chronic Central nervous system diseases.

Enrollment: 500 estimated patients

Sex: All

Ages: Under 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: under 12 years old.
• Both sex .
• Patients with chronic medical diseases.

Exclusion criteria

• Age: over 12years old.
• Patients with acute diseases.
• Pediatric with malignancy.
• chronic patients with surgical sequelae.

Trial design

500 participants in 7 patient groups

chronic cardiac patients

Description:

patients with chronic cardiac diseases affecting their groth parameters \& body mass index

Treatment:

Diagnostic Test: Growth parameters & body mass index

chronic renal patients

Description:

patients with chronic renal diseases affecting their growth parameters \& body mass index

Treatment:

Diagnostic Test: Growth parameters & body mass index

chronic respiratory diseases

Description:

patients with chronic respiratory diseases affecting their growth parameters \& body mass index

Treatment:

Diagnostic Test: Growth parameters & body mass index

chronic metabolic diseases

Description:

patients with chronic metabolic diseases affecting their growth parameters \& body mass index

Treatment:

Diagnostic Test: Growth parameters & body mass index

chronic neurological diseases

Description:

patients with chronic neurological diseases affecting their growth parameters \& body mass index

Treatment:

Diagnostic Test: Growth parameters & body mass index

chronic haematological diseases

Description:

patients with chronic haematological diseases affecting their growth parameters \& body mass index

Treatment:

Diagnostic Test: Growth parameters & body mass index

chronic gastro-intestinal diseases

Description:

patients with chronic gastro-intestinal diseases affecting their growth parameters \& body mass index

Treatment:

Diagnostic Test: Growth parameters & body mass index