GTI-2040 in Treating Patients With Relapsed, Refractory, or High-Risk Acute Leukemia, High-Grade Myelodysplastic Syndromes, or Refractory or Blastic Phase Chronic Myelogenous Leukemia

National Cancer Institute (NCI)

Status and phase: Completed; Phase 1

Conditions: Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Untreated Adult Acute Myeloid Leukemia; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; de Novo Myelodysplastic Syndromes; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Untreated Adult Acute Lymphoblastic Leukemia; Previously Treated Myelodysplastic Syndromes; Relapsing Chronic Myelogenous Leukemia; Secondary Myelodysplastic Syndromes; Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Secondary Acute Myeloid Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Recurrent Adult Acute Myeloid Leukemia; Acute Undifferentiated Leukemia

Treatments: Procedure: laboratory biomarker analysis; Drug: GTI-2040; Procedure: pharmacological study

Study type: Interventional

Funder types: NIH

Identifiers

NCT00459212

PHI-57

U01CA062505 (U.S. NIH Grant/Contract)

NCI-2009-00206

CDR0000539257

Details and patient eligibility

About

This phase I trial is studying the side effects and best dose of GTI-2040 in treating patients with relapsed, refractory, or high-risk acute leukemia, high-grade myelodysplastic syndromes, or refractory or blastic phase chronic myelogenous leukemia. Drugs used in chemotherapy, such as GTI-2040, work in different ways to stop the growth of cancer or abnormal cells, either by killing the cells or by stopping them from dividing.

Full description

OBJECTIVES:

I. Determine the maximum tolerated dose of GTI-2040 in patients with relapsed, refractory, or high-risk acute leukemia, high-grade myelodysplastic syndromes, or refractory or blastic phase chronic myelogenous leukemia.

II. Assess the toxicity and efficacy of this drug in these patients. III. Assess plasma and intracellular pharmacokinetics of this drug in these patients.

OUTLINE: This is a multicenter, dose-escalation study.

Patients receive GTI-2040 IV continuously on days 1-4 and 15-18. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of GTI-2040 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting toxicity.

Blood samples are collected on days 1, 4, 15, and 19 of course 1 for pharmacokinetic studies. Samples are analyzed by proteomic assay, dCTP pool measurement, and real-time polymerase chain reaction for mRNA of RRM2, RRM1, and p53R2.

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Diagnosis of 1 of the following:

  • Acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) refractory to primary standard induction therapy
  • Relapsed or refractory acute leukemia
  • Chronic myelogenous leukemia (CML) in blast crisis at diagnosis OR that failed prior aggressive induction chemotherapy

• Diagnosis of 1 of the following:

  • Acute leukemia secondary to preexisting hematologic condition or prior chemotherapy at diagnosis OR that failed prior aggressive induction chemotherapy
  • Advanced myelodysplastic syndromes (intermediate-1 or greater)
  • De novo acute leukemia (myeloid or nonmyeloid)

• Not a candidate for aggressive standard induction chemotherapy

• De novo AML or ALL (patients > 60 years of age)

• No suspected or proven active CNS leukemia

• ECOG performance status (PS) 0-2 OR Karnofsky PS 50-100%

• Life expectancy >= 8 weeks

• Bilirubin =< 1.5 mg/dL

• AST and ALT < 3 times upper limit of normal (ULN)

• Creatinine =< 1.5 times ULN

• No HIV positivity

• Fertile patients must use effective contraception

• No history of allergic reactions attributed to other phosphorothiolated oligonucleotides

• No uncontrolled intercurrent illness including, but not limited to, any of the following:

  • Ongoing, active, or poorly controlled infection
  • Symptomatic congestive heart failure
  • Unstable angina pectoris

• No uncontrolled intercurrent illness including, but not limited to, any of the following:

  • Cardiac arrhythmia
  • Poorly controlled pulmonary disease
  • Psychiatric illness or social situation that would preclude study compliance

• Recovered from all prior therapies

• Prior autologous or allogeneic stem cell transplantation allowed (No active graft-vs-host disease > grade 2)

• At least 2 weeks since prior and no concurrent cytotoxic chemotherapy

• At least 2 weeks since prior and no concurrent biologic therapy

• At least 2 weeks since any other prior investigational agent

• No other concurrent anticancer therapy, including radiotherapy or hormonal therapy

• Concurrent imatinib mesylate for CML allowed

• Not pregnant or nursing

• Negative pregancy test

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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24 participants in 1 patient group

Arm I

Experimental group

Description:

Patients receive GTI-2040 IV continuously on days 1-4 and 15-18.

Treatment:

Procedure: pharmacological study

Procedure: laboratory biomarker analysis

Drug: GTI-2040