GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors

National Cancer Institute (NCI)

Status and phase

Completed

Phase 1

Conditions

Stage IVB Colon Cancer

Stage IVA Rectal Cancer

Unspecified Adult Solid Tumor, Protocol Specific

Recurrent Colon Cancer

Stage IVB Rectal Cancer

Stage IIIC Rectal Cancer

Stage IVA Colon Cancer

Recurrent Rectal Cancer

Stage IIIC Colon Cancer

Treatments

Other: laboratory biomarker analysis

Biological: GTI-2040

Drug: capecitabine

Drug: oxaliplatin

Other: pharmacological study

Study type

Interventional

Funder types

NIH

Identifiers

NCT00084643

CDR0000365466 (Registry Identifier)

U01CA062505 (U.S. NIH Grant/Contract)

NCI-2012-03077

PHI-41

Details and patient eligibility

About

This phase I trial is studying the side effects and best dose of capecitabine when given together with GTI-2040 and oxaliplatin in treating patients with locally advanced or metastatic colorectal cancer or other solid tumors. Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. GTI-2040 may increase the effectiveness of chemotherapy by making tumor cells more sensitive to the drugs. Giving GTI-2040 together with oxaliplatin and capecitabine may kill more tumor cells

Full description

PRIMARY OBJECTIVES:

I. To establish the maximum tolerated (MTD) of a 21 day cycle of capecitabine given orally twice daily for 14 days in combination with oxaliplatin given intravenously on day 1 and GTI-2040 given as a continuous infusion over 14 days in patients with advanced metastatic solid tumors.

II. To describe the toxicities at each dose level studied.

SECONDARY OBJECTIVES:

I. To evaluate the pharmacokinetics of GTI-2040, capecitabine, and oxaliplatin when these are given in combination.

II. To evaluate levels of ribonucleotide reductase -M2 subunit (RR-M2) mRNA levels using TaqMan RT-PCR in peripheral blood mononuclear cells and in tumor samples (when available). TRF support will be required and sought.

III. To quantitate changes in dCTP levels in peripheral blood mononuclear cells during treatment as a surrogate marker of RR inhibition. TRF support will be required and sought.

OUTLINE: This is a multicenter, dose-escalation study of capecitabine.

Patients receive GTI-2040 IV continuously on days 1-14, oral capecitabine twice daily on days 2-15, and oxaliplatin IV over 2 hours on day 2 of the first course. In all subsequent courses, capecitabine is administered on days 1-14, oxaliplatin is administered on day 1, and GTI-2040 is administered as in course 1. Courses repeat every 21 days in the absence of disease progression and unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of capecitabine until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.

Enrollment

20 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients must have locally advanced or metastatic colorectal cancer that is not amenable to surgical treatment; selected patients with advanced disease in incurable cancers of other types may be considered
Patients must have histological or cytological proof of malignancy
Patients must have had at least one standard prior chemotherapy for locally advanced or metastatic disease with no prior oxaliplatin containing regimen; patients who relapse within 12 months of adjuvant therapy are eligible
Karnofsky performance status of >= 60%
Absolute neutrophil count > 1500/ul
Platelets > 100,000/ul
Total bilirubin within institutional normal limits
AST (SGOT)/ALT (SGPT) within 2.5 x institutional normal limits
Alkaline phosphatase within 2.5x institutional normal limits
Creatinine within institutional normal limits or a calculated creatinine clearance > 60 ml/min
Patients should have no greater than grade 1 neuropathy (CTCAE v3.0)
Ability to understand and the willingness to sign a written IRB approved consent document
Measurable disease not required
Previous chemotherapy must have been completed > 21 days before treatment on this study (> 6 weeks for mitomycin-c or nitrosoureas)
Life expectancy of at least 12 weeks

Exclusion criteria

Active or chronic hepatitis B or C
HIV positive patients receiving antiviral therapy because of possible pharmacokinetic interactions
Uncontrolled intercurrent illnesses including but not limited to ongoing or active infections, symptomatic congestive heart failure, unstable angina, or cardiac arrhythmia
Pregnant or nursing women are excluded due to the potential for teratogenic effects and for potential deleterious effects on the infant; woman of childbearing age and men must practice an effective form of contraception
Patients with known brain metastasis are excluded due their poor prognosis and due to possible neurologic sequelae that could confound the evaluation of the investigational treatment
Patients requiring anticoagulation are excluded as polyanions are known to inhibit clotting mechanisms and phosphorothioate oligonucleotide may act in a similar mechanism; patients receiving low dose prophylactic Coumadin (1 mg/day) may be included
Medical, social, of psychological factors that would interfere with consent and follow-up
Patients with a diagnosis of pulmonary fibrosis or a pulmonary interstitial process