Guidance of Ultrasound in Intensive Care to Direct Euvolemia (GUIDE)

The University of Texas System (UT)

Status: Completed

Conditions: Acute Kidney Injury

Treatments: Diagnostic Test: Usual care; Diagnostic Test: Serial ultrasound assessments for GDT

Study type: Interventional

Funder types: Other

Identifiers

NCT03938038

HSC-MS-19-0425

Details and patient eligibility

About

The purpose of this study is to assess the effectiveness of routine ultrasound assessments of volume status and fluid responsiveness for goal-directed therapy (GDT)-based fluid resuscitation in reducing acute kidney injury (AKI) incidence and duration in trauma patients in a teaching institution.

Enrollment: 415 patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Injured patients that are admitted to the trauma ICU

Exclusion criteria

• Incarceration
• Pregnancy

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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415 participants in 2 patient groups

Serial ultrasound assessments for GDT, then Usual Care

Active Comparator group

Treatment:

Diagnostic Test: Usual care

Diagnostic Test: Serial ultrasound assessments for GDT

Usual care, then Serial ultrasound assessments for GDT

Active Comparator group

Treatment:

Diagnostic Test: Usual care

Diagnostic Test: Serial ultrasound assessments for GDT