Guidelines Oriented Approach to Lipid Lowering (GOAL) in Canada

Canadian Heart Research Centre

Status: Completed

Conditions: Dyslipidemia

Treatments: Other: survey

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02537535

CHRC2014-GOAL Canada Study

Details and patient eligibility

About

Cross-sectional observational study designed to identify and describe the care gap in guideline-oriented low density lipoprotein cholesterol (LDL-C) management in Canadian patients at high cardiovascular risk.

Full description

This is a cross-sectional observational study designed to provide real-life data on the current management of dyslipidemia in high cardiovascular risk patients in routine clinical practice. Canadian guidelines recommend a target for LDL-C of ≤2.0 mmol/L (or ≥50% decrease) after treatment initiation in high-risk patients. The recommended first line treatment is statin therapy. Available data clearly indicates that up to 50% of high risk patients do not achieve this important target because of statin inadequacy or intolerance leading to non-adherence.

Therefore this program aims to provide further insights into the challenges Canadian physicians face in helping their high risk patients achieve guideline-recommended LDL-C.

Enrollment: 2,027 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Adults ≥ 18 years old 2. High risk for cardiovascular morbidity and mortality (at least one of the following):

2. Clinical vascular disease:

   • Coronary Artery Disease (CAD): history of myocardial infarction (MI), Coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), angiographic disease
   • Cerebrovascular Disease (CeVD): history of cerebrovascular accident (CVA) or transient ischemic attack (TIA), carotid surgery
   • Abdominal Aortic Aneurism (AAA): history of surgery/intervention
   • Peripheral Arterial Disease (PAD): history of surgery/intervention

3. Familial hypercholesterolemia defined as LDL-C > 5 mmol/L and one of:

   • typical physical findings (stigmata) such as tendon xanthomata, xanthelasma, and arcus corneae
   • personal history of early cardiovascular disease
   • family history of early cardiovascular disease or of marked hyperlipidemia

4. Receiving current optimal (maximal or maximal tolerated) statin therapy for at least 3 months prior to patient enrolment

5. LDL-C > 2.0 mmol/L measured within 6 months of patient enrolment date and while on (despite) maximal tolerated statin therapy (± other lipid modifying therapies).

6. Desire and ability to execute the consent to participate.

Exclusion criteria

1. Current treatment with PCSK9 inhibitor
2. Participation in an investigational study
3. Prior participation in the GOAL program