Gut Hormone Secretion and Macronutrients

University of Lausanne (UNIL)

Status

Completed

Conditions

Healthy Volunteers

Treatments

Other: glucose

Other: test meal

Other: protein

Other: fat

Other: control

Study type

Observational

Funder types

Other

Identifiers

NCT00869453

162/08/CE/FBM

Details and patient eligibility

About

The role of gut hormone (GLP-1, GIP, PYY...) in glucose homeostasis has been widely demonstrated. Furthermore modifications in their pattern of secretion seem to be involved in the improvement of glucose control in obese patients after bariatric surgery.

The purpose of this study is to assess the respective role of carbohydrate, fat and protein from a complete meal in gut hormones secretion.

Full description

The study is designed to asses the role of each individual macronutrient of a compete meal in gut hormones secretion in healthy volunteers.

8 healthy young male subjects will be studied on 5 different occasions. To asses the role of each macronutient the subjects will recieve one of the following test meal: a complete sandwich, the proteic part of this complete meal, the glucidic part and the lipidic part. The fifth test will be a fasting test.

To assess the entero-insular axis, a 5.5 hours hyperglycaemic clamp will be performed.

Enrollment

8 patients

Sex

Male

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male
18-35 years old
19 kg/m2 ≤ BMI ≤ 25 kg/m2
Healthy
Low to moderate physical activity
Non smokers

Exclusion criteria

Family history of diabetes mellitus
Any medication
Participation to blood spending or other clinical study in the 3 months before the beginning of this study
Consumption of drugs
Consumption of more than 50g of alcool in a week
Vegetarian or particular diet
Anamnèse d'intolérance alimentaire
Family history of food intolerance