Gut Hormones After Oral Versus Intravenous Amino Acids

Lund University

Status: Completed

Conditions: Normal Non-fluency

Treatments: Other: Intravenous amino acid administration; Other: Oral amino acid mixture

Study type: Interventional

Funder types: Other

Identifiers

NCT01366768

003

Details and patient eligibility

About

The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.

Full description

Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects. Samples are taken regularly for 300 min after administrations. Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.

Enrollment: 12 patients

Sex: Male

Ages: 20 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects

Exclusion criteria

• Diabetes
• Liver disease
• Kidney disease
• Thyroid disease

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 2 patient groups

Oral amino acid mixture

Experimental group

Description:

Oral administration of amino acid mixture in healthy volunteers

Treatment:

Other: Oral amino acid mixture

Intravenous amino acid administration

Experimental group

Description:

Intravenous infusion of amino acid mixture in healthy volunteers

Treatment:

Other: Intravenous amino acid administration