Gut Hormones and Bone Remodeling in Humans (KS-2)

University of Copenhagen

Status: Completed

Conditions: Healthy

Treatments: Other: GIP; Other: GLP-2+GIP; Other: Placebo; Other: GLP-2

Study type: Interventional

Funder types: Other

Identifiers

NCT03573934

UCHP-KS-2

Details and patient eligibility

About

Effects of GLP-2 and GIP on bone remodeling in healthy young men.

Full description

We will investigate acute effects of GLP-2 and GIP on bone remodeling in healthy young men.

Enrollment: 10 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Age between 20 and 40 years old Caucasian Healthy BMI between 18.5 and 24.9 kg/m2.

Exclusion criteria

Chronic disease Smoking Medication Weight change more than 3 kg whitin the last 3 months Overweight surgery Intestinal surgery Hgb<8,0 mmol/L Decreased renal function.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 4 patient groups, including a placebo group

GLP-2

Experimental group

Description:

Glucagon-Like Peptide-2 (GLP-2) injection

Treatment:

Other: GLP-2

GIP

Experimental group

Description:

Glucose-dependent Insulinotropic polypeptide (GIP) injection

Treatment:

Other: GIP

GLP-2+GIP

Experimental group

Description:

GLP-2+GIP injection

Treatment:

Other: GLP-2+GIP

Placebo

Placebo Comparator group

Description:

Placebo injection

Treatment:

Other: Placebo